Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & BLI & MALS verified)

DESCRIPTION

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

DETAILS

Tag: C-10×His | Native
Host: HEK293
Size: 50ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Human FCGRT&B2M Heterodimer Protein, His Tag (FCN-H52W7) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # P55899-1 (FCGRT) & P61769-1 (B2M)).
Storage: -20℃
Category: MABSol® Fc Receptors
Molecule: FcRn (FCGRT & B2M)
Accession: NP_001129491.1 (FCGRT) & NP_004039.1 (B2M)
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 24 months in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
Swiss-prot: P55899-1 (FCGRT) & P61769-1 (B2M)
Package Size: 50ug*1
Characteristics: Human FCGRT&B2M Heterodimer Protein, His Tag, produced by co-expression of FCGRT and B2M, has a calculated MW of 32.3 kDa (FCGRT) and 11.7 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subunit Beta-2 microglobulin (B2M) contains no tag at the C-terminus. The reducing (R) protein migrates as 33 kDa (FCGRT) and 10 kDa (B2M) respectively due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 32.3 kDa (FCGRT) & 11.7 kDa (B2M)
Shipping Condition: RT
Species Reactivity: Human
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