Cynomolgus Growth Hormone R (GHR) Protein, His Tag

DESCRIPTION

Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 100ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Cynomolgus Growth Hormone R, His Tag (GHR-C52H1) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Tyr 264 (Accession # EHH62357.1).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Growth Hormone R
Accession: EHH62357.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Phe 19 - Tyr 264
Swiss-prot: G8F4Z3
Package Size: 100ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.2 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 30.2 kDa
Shipping Condition: RT
Species Reactivity: Cynomolgus
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