DESCRIPTION

• Tag: C-Twin Strep | C-10×His
• Host: HEK293
• Size: 50ug
• Buffer: PBS, pH7.4
• Format: Powder
• Purity: 90%
• Storage: -20℃
• Category: Viral Proteins
• Molecule: Glycoprotein H&L
• Conjugate: Unconjugated
• Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Background: Human cytomegalovirus (HCMV), a prototypical beta-herpes virus, is a major cause of morbidity and mortality in immunocompromised transplant recipients and congenitally infected fetuses.Different HCMV glycoprotein complexes are capable of meditating entry through interaction with cell-specific receptors on a panel of host cells. The pentamer (gH/gL/UL128/UL130/UL131A) mediates HCMV entry into epithelial, endothelial, and myeloid cells by its binding to neuropilin 2 (Nrp2). The trimer (gH/gL/gO) can mediate infection of all cell types by binding to platelet-derived growth factor-alpha (PDGFRα). Both pentamer and trimer need to interact with the glycoprotein B (gB), the fusogenic protein, to trigger the virus and host cell membrane fusion.
• Exp Region: Arg 24 - Leu 720 & Val 31 - Arg 278
• Swiss-prot: P12824,P16832
• Characteristics: This protein . The protein has a calculated MW of 82.6 kDa & 29.5 kDa. The protein migrates as 30-38 kDa and 90-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin Level: 1.0 EU per μg
• Molecular Weight: 82.6 kDa & 29.5 kDa
• Shipping Condition: RT
• Species Reactivity: HHV-5
• Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html