Methylcarbamyl PAF C-16

DESCRIPTION

Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.{613,4944} It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in PRP.{613} In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of MAPK.{4944} Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.{4944}

DETAILS

Inchi: InChI=1S/C26H55N2O7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-32-23-25(35-26(29)27-2)24-34-36(30,31)33-22-20-28(3,4)5/h25H,6-24H2,1-5H3,(H-,27,29,30,31)/t25-/m1/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Lipids|Glycerophospholipids||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Lipid Biochemistry|Glycerophospholipids
Smiles: CCCCCCCCCCCCCCCCOC[C@@H](OC(NC)=O)COP(OCC[N+](C)(C)C)([O-])=O
Inchikey: FNFHZBKBDFRYHS-RUZDIDTESA-N
Cas Number: 91575-58-5
Formulation: A solution in ethanol
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C26H55N2O7P
Formula Weight: 538.7
Shelf Life Days: 365