Penbutolol (hemisulfate)

DESCRIPTION

A β-adrenergic and 5-HT1A receptor antagonist (IC50s = 2.8 and 9.9 nM, respectively); inhibits isoprenaline-induced adenylate cyclase activity in guinea pig myocardial membranes (Ki = 2.4 nM); reduces basal renin activity and blood pressure in spontaneously hypertonic rats; decreases isolation-induced aggressive behavior in mice (ED50 = 56 µmol/kg) and reverses 8-hydroxy-DPAT- and TFMPP-induced reductions in aggression (ED50s = 8.1 and 2.1 µmol/kg, respectively)

DETAILS

Inchi: InChI=1S/2C18H29NO2.H2O4S/c2*1-18(2,3)19-12-15(20)13-21-17-11-7-6-10-16(17)14-8-4-5-9-14;1-5(2,3)4/h2*6-7,10-11,14-15,19-20H,4-5,8-9,12-13H2,1-3H3;(H2,1,2,3,4)/t2*15-;/m00./s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Neuroscience|Behavioral Neuroscience
Smiles: O[C@@H](CNC(C)(C)C)COC1=C(C2CCCC2)C=CC=C1.O=S(O)(O)=O.O[C@@H](CNC(C)(C)C)COC3=C(C4CCCC4)C=CC=C3
Inchikey: FEDSNBHHWZEYTP-ZFQYHYQMSA-N
Cas Number: 38363-32-5
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C18H29NO2 • 1/2H2SO4
Formula Weight: 340.5
Shelf Life Days: 1460