ILF3 Antibody (Center) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3609
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ILF3
Other Names: Interleukin enhancer-binding factor 3, Double-stranded RNA-binding protein 76, DRBP76, M-phase phosphoprotein 4, MPP4, Nuclear factor associated with dsRNA, NFAR, Nuclear factor of activated T-cells 90 kDa, NF-AT-90, Translational control protein 80, TCP80, ILF3, DRBF, MPHOSPH4, NF90
Availability: 2 weeks
Bio Background: ILF3 gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45kDa and 90 kDa proteins, the larger of which is the product of this protein. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced.
Bio References: Kiesler,P., et.al., J. Biol. Chem. 285 (11), 8256-8267 (2010)Wang,P., et.al., J. Virol. 83 (16), 7850-7861 (2009)Sakamoto,S., et.al., Mol. Cell. Biol. 29 (13), 3754-3769 (2009)
Primary Accession: Q12906