FOXA2 Blocking Peptide (C-term)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3170
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: FOXA2
Other Names: Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B, Forkhead box protein A2, Transcription factor 3B, TCF-3B, FOXA2, HNF3B, TCF3B
Availability: 2 weeks
Bio Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Bio References: Yamada S.,et al.Diabetologia 43:121-124(2000). Hinokio Y.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases. Navas M.A.,et al.Hum. Hered. 50:370-381(2000). Deloukas P.,et al.Nature 414:865-871(2001). Wolfrum C.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003).
Other Accession: P32182; P35583
Primary Accession: Q9Y261
Targetspecificity: The synthetic peptide sequence is selected from aa 355-369 of HUMAN FOXA2