HDAC5 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 10014
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: HDAC5
Other Names: Histone deacetylase 5, HD5, Antigen NY-CO-9, HDAC5, KIAA0600
Availability: 2 weeks
Bio Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with the HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This protein is thought to be associated with colon cancer.
Bio References: Berger, I., et al., J. Biol. Chem. 278(20):17625-17635 (2003).Zhang, C.L., et al., Mol. Cell. Biol. 22(20):7302-7312 (2002).Lemercier, C., et al., J. Biol. Chem. 277(24):22045-22052 (2002).Huang, Y., et al., Cancer Res. 62(10):2913-2922 (2002).Grozinger, C.M., et al., Proc. Natl. Acad. Sci. U.S.A. 97(14):7835-7840 (2000).
Primary Accession: Q9UQL6
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1105a was selected from the N-term region of human HDAC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.