ASCL1 (Achaete-scute homolog 1) Blocking Peptide (C-term D220)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 429
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ASCL1
Other Names: Achaete-scute homolog 1, ASH-1, hASH1, Class A basic helix-loop-helix protein 46, bHLHa46, ASCL1, ASH1, BHLHA46, HASH1
Availability: 2 weeks
Bio Background: ACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.
Bio References: Sriuranpong, V., et al., Mol. Cell. Biol. 22(9):3129-3139 (2002). Westerman, B.A., et al., Clin. Cancer Res. 8(4):1082-1086 (2002). Chen, H., et al., Cell Growth Differ. 8(6):677-686 (1997). Borges, M., et al., Nature 386(6627):852-855 (1997). Renault, B., et al., Genomics 30(1):81-83 (1995).
Other Accession: Q90259; P19359; Q02067; NP_004307
Primary Accession: P50553
Targetspecificity: The synthetic peptide sequence is selected from aa 220~236 of HUMAN ASCL1