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E6779Hu

Human Sequestosome-1, SQSTM1 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357).

DETAILS

  • GeneID: 8878
  • Species: Human
  • Storage: 2-8ºC
  • MASS(Da): 47,687
  • Synonyms: A170;DMRV;EBI3-associated protein of 60 kDa;EBIAP;FTDALS3;NADGP;OSIL;p60;p62;p62B;PDB3;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;Sequestosome-1;SQSTM1;Ubiquitin-binding protein p62
  • Assay Time: 1h 30m
  • Assay Type: Sandwich
  • Gene Names: SQSTM1
  • Reactivity: Human
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 0.023ng/ml
  • Target Protein: SQSTM1
  • Detection Range: 0.05-30ng/ml
  • Full Product Name: Sequestosome-1
  • Standard Solution: 32ng/ml
  • UniProt Accession: Q13501