SETDB1 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 9869
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: SETDB1
Other Names: Histone-lysine N-methyltransferase SETDB1, ERG-associated protein with SET domain, ESET, Histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, Lysine N-methyltransferase 1E, SET domain bifurcated 1, SETDB1, KIAA0067, KMT1E
Availability: 2 weeks
Bio Background: The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure. It was originally identified as part of a larger conserved region present in the Drosophila Trithorax protein and was subsequently identified in the Drosophila Su(var)3-9 and 'Enhancer of zeste' proteins, from which the acronym SET is derived. Studies have suggested that the SET domain may be a signature of proteins that modulate transcriptionally active or repressed chromatin states through chromatin remodeling activities.
Bio References: Ichimura, T., et al., J. Biol. Chem. 280(14):13928-13935 (2005).Sarraf, S.A., et al., Mol. Cell 15(4):595-605 (2004).Wang, H., et al., Mol. Cell 12(2):475-487 (2003).Schultz, D.C., et al., Genes Dev. 16(8):919-932 (2002).Yang, L., et al., Biochem. J. 369 (PT 3), 651-657 (2003) (): ().
Primary Accession: Q15047
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP1073b was selected from the C-term region of human SETDB1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.