FITC-Labeled Human Siglec-2 / CD22 Protein, Fc Tag

DESCRIPTION

B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

DETAILS

Tag: C-Fc
Host: HEK293
Size: 25ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: FITC-Labeled Human Siglec-2, Fc Tag (CD2-HF254) is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 687 (Accession # P20273-1). It is the FITC labeled form of Human Siglec-2, Fc Tag (Cat. No. CD2-H5253).
Storage: -20℃, aviod light
Category: Fluorescent labeled protein
Molecule: Siglec-2
Accession: NP_001762.2
Conjugate: FITC Labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Asp 20 - Arg 687
Swiss-prot: P20273-1
Package Size: 25ug*1
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 101.6 kDa. The protein migrates as 130-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 101.6 kDa
Shipping Condition: RT
Species Reactivity: Human
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