MKK7 Antibody (C-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 5609
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MAP2K7
Other Names: Dual specificity mitogen-activated protein kinase kinase 7, MAP kinase kinase 7, MAPKK 7, JNK-activating kinase 2, MAPK/ERK kinase 7, MEK 7, Stress-activated protein kinase kinase 4, SAPK kinase 4, SAPKK-4, SAPKK4, c-Jun N-terminal kinase kinase 2, JNK kinase 2, JNKK 2, MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
Availability: 2 weeks
Bio Background: MKK7 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses.
Bio References: Sundarrajan, M., et al., Arthritis Rheum. 48(9):2450-2460 (2003).Yang, J.J., Biochem. Biophys. Res. Commun. 297(1):105-110 (2002).Kawaguchi, M., et al., J. Biol. Chem. 277(18):15229-15232 (2002).Tournier, C., et al., Genes Dev. 15(11):1419-1426 (2001).Chayama, K., et al., Proc. Natl. Acad. Sci. U.S.A. 98(8):4599-4604 (2001).
Primary Accession: O14733
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP7918a was selected from the C-term region of human MKK7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.