SPPL2a Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 84888
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: SPPL2A
Other Names: Signal peptide peptidase-like 2A, SPP-like 2A, SPPL2a, 3423-, Intramembrane protease 3, IMP-3, Presenilin-like protein 2, SPPL2A, IMP3, PSL2
Availability: 2 weeks
Bio Background: By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus.
Bio References: Grigorenko, A. P., et al. Biochemistry 67: 826-834 (2002).
Primary Accession: Q8TCT8
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP6312a was selected from the N-term region of human SPPL2a. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.