Cynomolgus LIGHT / TNFSF14 Protein, His Tag, active trimer (MALS verified)

DESCRIPTION

Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes.

DETAILS

Tag: N-10×His
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Cynomolgus LIGHT Protein, His Tag (LIT-C5244) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # E9NVF7).
Storage: -20℃
Category: Immune Checkpoint Proteins
Molecule: LIGHT
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Asp 74 - Val 240
Swiss-prot: E9NVF7
Package Size: 500ug*2
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 58.6 kDa. The protein migrates as 63-66 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 58.6 kDa
Shipping Condition: RT
Species Reactivity: Cynomolgus
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