ATP6V0A4 Blocking Peptide (Center)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 50617
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: ATP6V0A4
Other Names: V-type proton ATPase 116 kDa subunit a isoform 4, V-ATPase 116 kDa isoform a4, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4, Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform, ATP6V0A4, ATP6N1B, ATP6N2
Availability: 2 weeks
Bio Background: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
Bio References: Andreucci, E., et al. Pediatr. Nephrol. 24(11):2147-2153(2009) Hinton, A., et al. J. Biol. Chem. 284(24):16400-16408(2009) Su, Y., et al. Am. J. Physiol. Renal Physiol. 295 (4), F950-F958 (2008) : Norgett, E.E., et al. J. Biol. Chem. 282(19):14421-14427(2007) Smith, A.N., et al. J. Am. Soc. Nephrol. 16(5):1245-1256(2005) Forgac, M. J. Biol. Chem. 274(19):12951-12954(1999) Nelson, N., et al. Physiol. Rev. 79(2):361-385(1999) Kane, P.M. J. Bioenerg. Biomembr. 31(1):3-5(1999) Finbow, M.E., et al. Biochem. J. 324 (PT 3), 697-712 (1997) : Stevens, T.H., et al. Annu. Rev. Cell Dev. Biol. 13, 779-808 (1997) :
Other Accession: NP_570856.2;NP_570855.2
Primary Accession: Q9HBG4
Targetspecificity: The synthetic peptide sequence is selected from aa 250-261 of HUMAN ATP6V0A4