Phospho-HSPB1-pS82 Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 3315
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: HSPB1
Other Names: Heat shock protein beta-1, HspB1, 28 kDa heat shock protein, Estrogen-regulated 24 kDa protein, Heat shock 27 kDa protein, HSP 27, Stress-responsive protein 27, SRP27, HSPB1, HSP27, HSP28
Availability: 2 weeks
Bio Background: In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.
Bio References: Wano, C., et al., Exp. Cell Res. 298(2):584-592 (2004). Evgrafov, O.V., et al., Nat. Genet. 36(6):602-606 (2004). Song, H., et al., Biochem. Biophys. Res. Commun. 314(1):143-150 (2004). Chauhan, D., et al., Blood 102(9):3379-3386 (2003). Van Why, S.K., et al., J. Am. Soc. Nephrol. 14(1):98-106 (2003).
Primary Accession: P04792